NOTICIAS CIENCIAS FISIOLÓGICAS

FISIOLOGÍA MÉDICA

• Metabolic Syndrome in Hypertriglyceridemic Rats: Effects of Antioxidants 09/06/2023
  Long-lasting disturbances in lipid and glucose metabolism present in metabolic syndrome (MetS) lead to serious cardiovascular diseases. The study was aimed to evaluate the effect of natural antioxidant vitamin E (VitE, 100 mg/kg/day, p.o.) on basal biochemical and physiological parameters characterizing MetS and on the changed function of the heart. Furthermore, the possible potentiation of […]
  Z Brnoliakova
• Models for barrier understanding in health and disease in lab-on-a-chips 09/06/2023
  The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exist to investigate barrier function in vivo and in vitro. To investigate barrier function in a highly reproducible manner, ethically, and high throughput, researchers have […]
  J Ponmozhi
• Extracellular vesicles arising from apoptosis: forms, functions, and applications 09/06/2023
  Extracellular vesicles (EVs) are lipid bilayer-enclosed subcellular bodies produced by most, if not all cells. Research over the last two decades has recognised the importance of EVs in intercellular communication and horizontal transfer of biological material. EVs range in diameter from tens of nanometres up to several micrometres and are able to transfer a spectrum […]
  Christopher D Gregory
• Effects of Iron Nanoparticles Administration on Ischemia/Reperfusion Injury in Isolated Hearts of Male Wistar Rats 09/06/2023
  Iron is an essential mineral participating in numerous biological processes in the organism under physiological conditions. However, it may be also involved in the pathological mechanisms activated in various cardiovascular diseases including myocardial ischemia/reperfusion (I/R) injury, due to its involvement in reactive oxygen species (ROS) production. Furthermore, iron has been reported to participate in the […]
  L Kindernay
• Bilateral Globus Pallidus Externus Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome: An Open Clinical Trial 09/06/2023
  CONCLUSIONS: Bilateral GPe-DBS proved to be low risk and quite effective for treating TS and comorbidities, ratifying the pathophysiological hypothesis that led to this study. Moreover, it compared favorably with DBS of other targets currently in use.
  Osvaldo Vilela-Filho
• CIARA: a cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data 09/06/2023
  A powerful feature of single-cell genomics is the possibility of identifying cell types from their molecular profiles. In particular, identifying novel rare cell types and their marker genes is a key potential of single-cell RNA sequencing. Standard clustering approaches perform well in identifying relatively abundant cell types, but tend to miss rarer cell types. Here, […]
  Gabriele Lubatti
• The role of apoptosis in the pathogenesis of osteoarthritis 09/06/2023
  CONCLUSION: This review offers a better molecular delineation of apoptotic processes that may help in designing new therapeutic options for OA treatment.
  Si-Qi Xiao
• Rudolf Richard Buchheim, the founder of pharmacology 09/06/2023
  Today, the University of Tartu (earlier Dorpat) belongs among the 250 best universities of the world. Its international team of pharmacologists uses powerful confocal microscopes to study apoptosis and cell death within an international consortium. Science is working on solutions to fight Alzheimer disease, which is a torture for humankind. For this to happen today, […]
  Maie Toomsalu
• Recent Advances in Formulations for Long-Acting Delivery of Therapeutic Peptides 09/06/2023
  Recent preclinical and clinical studies have focused on the active area of therapeutic peptides due to their high potency, selectivity, and specificity in treating a broad range of diseases. However, therapeutic peptides suffer from multiple disadvantages, such as limited oral bioavailability, short half-life, rapid clearance from the body, and susceptibility to physiological conditions (e.g., acidic […]
  Parham Sahandi Zangabad
• The impact of frailty on outcomes following laparoscopic repair of 'giant' paraesophageal hernias 09/06/2023
  CONCLUSION: Increased frailty as assessed by the mFI is correlated with length of stay and discharge destination following laparoscopic repair of giant PEH in patients > 65. Complication rates were comparable for both frail and non-frail cohorts.
  Thomas Q Xu